منابع مشابه
Nuclear Architecture and Epigenetics of Lineage Choice
Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...
متن کاملEpigenetics
By the time the reader reaches Chapter 20, which focuses specifically on cancer, the mechanisms and symptoms of cancer are relatively easy to understand. Chapter 20 covers topics such as the cellular phenotypes of cancer, genes linked to cancer, and cancer treatment. While the primary literature citations at the end of the chapter will provide good starting points for the curious student, a mor...
متن کاملEpigenetics
In this issue we focus on the topic of Epigenetics, the study of heritable phenotypic traits not encoded by the genetic sequence. While every cell in your body has a copy of your genetic code in the form of DNA, many of the unique features between different cell types and between different individuals arise from unique patterns of gene expression. In recent decades, it has become increasingly c...
متن کاملHIGHLIGHTED TOPIC Epigenetics in Health and Disease Epigenetics and cancer
Kanwal R, Gupta S. Epigenetics and cancer. J Appl Physiol 109: 598–605, 2010. First published March 4, 2010; doi:10.1152/japplphysiol.00066.2010.— Epigenetic modifications are central to many human diseases, including cancer. Traditionally, cancer has been viewed as a genetic disease, and it is now becoming apparent that the onset of cancer is preceded by epigenetic abnormalities. Investigators...
متن کاملEpigenetics
Emerging evidence is shedding light on a large and complex network of epigenetic modifications at play in human stem cells. This "epigenetic landscape" governs the fine-tuning and precision of gene expression programs that define the molecular basis of stem cell pluripotency, differentiation and reprogramming. This review will focus on recent progress in our understanding of the processes that ...
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ژورنال
عنوان ژورنال: Endocrine Disruptors
سال: 2013
ISSN: 2327-3747
DOI: 10.4161/endo.27347